Enzymes and membrane proteins of ADSOL-preserved red blood cells

Enzymes and membrane proteins of ADSOL-preserved red blood cells.

CONTEXT The preservative solution ADSOL (adenine, dextrose, sorbitol, sodium chloride and mannitol) maintains red cell viability for blood trans-fusion for 6 weeks. It would be useful to know about its preservation qualities over longer periods. OBJECTIVE To determine some red cell biochemical parameters for peri-ods of up to 14 weeks in order to determine whether the red cell metabo-lism int...

Metabolomics of ADSOL (AS-1) red blood cell storage.

Population-based investigations suggest that red blood cells (RBCs) are therapeutically effective when collected, processed, and stored for up to 42 days under validated conditions before transfusion. However, some retrospective clinical studies have shown worse patient outcomes when transfused RBCs have been stored for the longest times. Furthermore, studies of RBC persistence in the circulati...

Effect of low dose X-ray on membrane fluidity of thalassemic red blood cells

Background: Chest X-ray is one of the examinations required for an annual health checkup. The interaction of radiation to the medium produces free radicals, which consequently causes biological changes either structural or properties of the cells. Whether the radiation from Chest X-ray upright technique affects the plasma membrane fluidity of thalassemic red blood cells (RBCs) is still unclear....

Rheologic changes of hypothermic preserved red blood cells

Role of the phosphorylation of red blood cell membrane proteins.

The red blood cell membrane is composed of a lipid bilayer and two types of proteins: the integral proteins, which extend all the way across the lipid bilayer, and the proteins which do not penetrate the lipid bilayer and for this reason are called external proteins. The most important external proteins make up the membrane skeleton on which depend the membrane stability and the shape and defor...